Solutions

Life science

Accelerate therapy development and adoption

Generate regulatory grade evidence across the product lifecycle with the most representative, complete, and timely patient journey data.

How we can help

Clinical trials

Optimize and de-risk clinical trials in real time with the most complete, regulatory-grade real-world data.

  • De-risk trials with real-world feasibility modeling, real-time site- and provider-level visibility, and partnership opportunities with leading US health systems.
  • Prevent failed trials and reduce zero-enrollment sites by dynamically modeling complex feasibility before launch, and continuously optimize post-enrollment performance with daily refreshed data.
  • Extend trial value beyond the study window by generating ongoing evidence for prospective research and post-market studies, or by linking registries for long-term patient follow-up.

Testing I/E criteria to de-risk clinical programs

Diagram detailing inclusion and exclusion criteria applied to a heart failure population in Truveta Data. The criteria encompass medication use, length of stay, outpatient encounters, laboratory results, comorbidities, and device use. The visual representation offers a comprehensive overview of the selection criteria, aiding in understanding the parameters used to define the study population.

Sample heart failure population with inclusion/exclusion criteria applied

 Read the case study

HEOR

Generate robust evidence on cost-effectiveness and outcomes to accelerate regulatory approval and reimbursement.

  • Leverage linked EHR and closed claims, alongside AI, to evaluate real-world outcomes and cost effectiveness of drugs and devices.
  • Generate evidence to support reimbursement decisions, including CMS national coverage determinations and label/indication expansion.
  • Train AI models to predict treatment response, disease progression, and long-term outcomes.

Comparing real-world treatment effectiveness

Mean body weight change from baseline in treated, propensity score matched patients.

 Read the research

Unmet needs

Monitor real-world treatment patterns, access barriers, and market dynamics to maximize patient reach.  

  • Analyze real-world treatment patterns and barriers to timely intervention to accelerate therapy adoption.
  • Evaluate disparities in access by examining utilization trends across demographics, geography, and payer types.
  • Develop medical education addressing trends in patient adherence, discontinuation, and switching.

Analyzing therapy discontinuation and reinitiation trends

 

Proportion of patients discontinuing and reinitiating GLP-1 RAs within 2 years

Read the research

Safety

Fulfill post-market regulatory requirements and accelerate safety assessments with real-time data.

  • Streamline post-market safety requirements, including PASS and PMR studies, reducing reliance on costly trials and registries.
  • Quickly identify and assess potential safety signals using real-time data.
  • Assess long-term safety across diverse patient populations with complete EHR data linked to closed claims, SDOH, and mortality data.
  • Predict adverse event risks and simplify case processing with AI modeling.

Assessing the safety of novel interventions

Comparative bleeding incidence 7 days post-procedure for pulmonary embolism interventions

 Read the case study

R&D

Accelerate drug and device innovation with AI and linked EHR and multiomics, closed claims, and SDOH data.

  • Identify clinically relevant biomarkers and precision medicine opportunities with integrated genomic and phenotypic data.
  • Track real-world disease progression to optimize early-stage development.
  • Train AI models to accelerate target discovery and device innovation with data from representative populations.

Genetic association Manhattan plot

Genome-wide associations linking genetic variants to disease risk and therapeutic targets

How we can help

Clinical trials

HEOR

Unmet need

Safety

R&D

Clinical trials

Optimize and de-risk clinical trials in real time with the most complete, regulatory-grade real-world data.

^
De-risk trials with real-world feasibility modeling, real-time site- and provider-level visibility, and partnership opportunities with leading US health systems.
^
Prevent failed trials and reduce zero-enrollment sites by dynamically modeling complex feasibility before launch, and continuously optimize post-enrollment performance with daily refreshed data.
^
Extend trial value beyond the study window by generating ongoing evidence for prospective research and post-market studies, or by linking registries for long-term patient follow-up.

Testing I/E criteria to de-risk clinical programs

Diagram detailing inclusion and exclusion criteria applied to a heart failure population in Truveta Data. The criteria encompass medication use, length of stay, outpatient encounters, laboratory results, comorbidities, and device use. The visual representation offers a comprehensive overview of the selection criteria, aiding in understanding the parameters used to define the study population.

Sample heart failure population with inclusion/exclusion criteria applied

HEOR

Generate robust evidence on cost-effectiveness and outcomes to accelerate regulatory approval and reimbursement.

^

Leverage linked EHR and closed claims, alongside AI, to evaluate real-world outcomes and cost effectiveness of drugs and devices.

^

Generate evidence to support reimbursement decisions, including CMS national coverage determinations and label/indication expansion.

^
Train AI models to predict treatment response, disease progression, and long-term outcomes.
Comparing real-world treatment effectiveness
October 2023 Respiratory Viruses hospitalizations trend report
Mean body weight change from baseline in treated, propensity score matched patients.

Unmet need

Monitor real-world treatment patterns, access barriers, and market dynamics to maximize patient reach.

^
Analyze real-world treatment patterns and barriers to timely intervention to accelerate therapy adoption.
^
Evaluate disparities in access by examining utilization trends across demographics, geography, and payer types.
^
Develop medical education addressing trends in patient adherence, discontinuation, and switching.
Analyzing therapy discontinuation and reinitiation trends
Truveta Research explores the potential impact of Adderall shortage using EHR data to explore trends in prescription fills for patients with ADHD
Proportion of patients discontinuing and reinitiating GLP-1 RAs within 2 years

Safety

Fulfill post-market regulatory requirements and accelerate safety assessments with real-time data.

^

Streamline post-market safety requirements, including PASS and PMR studies, reducing reliance on costly trials and registries.

^
Quickly identify and assess potential safety signals using real-time data.
^
Assess long-term safety across diverse patient populations with complete EHR data linked to closed claims, SDOH, and mortality data.
^
Predict adverse event risks and simplify case processing with AI modeling.

Assessing the safety of novel interventions

Comparison table from a scientific publication using Truveta Data to illustrate bleeding events associated with two medical devices for treating pulmonary embolism: the USCDT (Unspecified Superiority Clot Dissolver) and MT (Standard Mechanical Thrombectomy). The data is presented for two distinct time periods—2009 to 2023 (primary analysis) and 2018 to 2023 (contemporary analysis). Bleeding events are categorized into six types, with results presented as counts and percentages. Statistical significance is indicated by p-values, providing insights into the safety profiles of the two devices over time.

Comparative bleeding incidence 7 days post-procedure for pulmonary embolism interventions

R&D

Accelerate drug and device innovation with AI and linked EHR and multiomics, closed claims, and SDOH data.

^
Identify clinically relevant biomarkers and precision medicine opportunities with integrated genomic and phenotypic data.
^
Track real-world disease progression to optimize early-stage development.
^
Train AI models to accelerate target discovery and device innovation with data from representative populations.
Genetic association Manhattan plot
Population clustering visualization featuring two panes in Truveta Studio. The first pane explores the absence or presence of Type 2 diabetes, with distinct clusters or patterns representing different groups within the population. The second pane depicts heart failure rates, offering insights into how these rates vary or cluster within the analyzed population. The visualization provides a comprehensive overview of the relationships between Type 2 diabetes and heart failure prevalence.
Genome-wide associations linking genetic variants to disease risk and therapeutic targets

Why Truveta

Complete data

Truveta delivers regulatory grade representative, complete, and timely patient journeys across 120M patients from EHR data and 200M patients from closed claims.

Regulatory grade, audit ready

Aligned with final guidance published by the FDA, Truveta offers rigorous standards of data quality and provenance, and audit-readiness.

Notes and images

With access to 7B+ notes and 100M+ images integrated with EHR data, researchers can access unprecedented depth of clinical context for patient journeys.

Trusted by leading life science, public health, and healthcare organizations